To investigate the result of IKK2 inhibitor VIII (HY-13060, Medchem Express, Monmouth Junction, NJ) on OA enhancement, MLI surgical procedures have been executed in twelve-week-aged C57BL/6 WT mice. The mice ended up injected with IKK2 inhibitor VIII (two?mg/kg, IP) every single alternate working day for five months. OARSI scoring was carried out b